We are pioneering methods for measuring and tracking seizure risk in epilepsy on time scales ranging from milliseconds to months, including modulation by individual cycles of fast sleep oscillations, daily circadian rhythms, and monthly multidian oscillations.

Using a novel network wide recording array, we aim to identify and catalog unique brain states, with the overall goal of understanding the functional organization of the brain.

We are developing advanced techniques for chronic network-wide recording using individually placed microwires. Microwires are small, flexible, and do less damage to the brain, ideal for low-density, high coverage recording constellations. In order to increase coverage, precision, and ease of use, we are actively developing robotic systems for automated placement of dispersed microelectrode constellations for whole brain recording in rodents and humans.

During sleep, a carefully orchestrated sequence of events occurs that extracts useful information from recent experiences and uses it to refine our global model of the world. We are interested in the mechanistic underpinnings of this process with the hope that a detailed understanding might provide clues that help explain how the brain is capable of learning with few examples.